胆囊收缩素(英语:cholecystokinin,简称CCK或CCK-PZ;词源来自于希腊语的chole,胆汁之意;cysto,囊状之意;kinin,移动之意;组合起来的意义为“移动胆汁之囊”)是一种消化系统当中的肽类激素,可以促进脂肪与蛋白质的消化。胆囊收缩素在此之前名为促胰酶素(pancreozymin),是由小肠的黏膜上皮细胞当中的I细胞所合成,并由十二指肠分泌;这会导致从胰脏与胆囊,各自释放消化酶与胆汁。胆囊收缩素也是一种食欲抑制剂。最近的证据暗示,胆囊收缩素在促进鸦片类药物的药物容许量,如吗啡和海洛因,扮演着重要角色,并且在经历鸦片类药物停药后的疼痛过敏经历有着部分的关联性[1][2]。
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- ↑ Kissin I, Bright CA, Bradley EL. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth. Analg. 2000, 91 (1): 110–6. PMID 10866896. doi:10.1097/00000539-200007000-00021.
- ↑ Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S. Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats. J. Pharmacol. Sci. 2007, 104 (2): 159–66. PMID 17558184. doi:10.1254/jphs.FP0070475.