促卵泡激素β亚基

求闻百科，共笔求闻
Follicle stimulating hormone, beta polypeptide
促卵泡激素，β多肽
PDB rendering based on 1fl7.
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 FSHB
扩展标识 遗传学：136530 同源基因：430 GeneCards: FSHB Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 2488 14308
Ensembl ENSG00000131808 ENSMUSG00000027120
UniProt P01225 Q60687
mRNA序列 NM_000510 NM_008045
蛋白序列 NP_000501 NP_032071
基因位置 Chr 11:
30.25 – 30.26 Mb		 Chr 2:
107.06 – 107.06 Mb
PubMed查询 [1] [2]

促卵泡激素β亚基（英语：Follitropin subunit beta 或 follicle-stimulating hormone beta subunit 缩写FSH-B）是一种由人类基因FSHB 编码的蛋白质[1][2][3]。其RNA的选择性剪接可形成该蛋白的两种蛋白异型体。

功能

垂体糖蛋白激素家族包括促卵泡激素、黄体生成素、人绒毛膜促性腺激素和促甲状腺激素，所有这些糖蛋白激素都包括一个共同的α亚基和一个特异的β亚基。FSHB 基因编码的就是促卵泡激素的β亚基。 In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production.[3]

参考文献

  1. ↑ Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB. DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. DNA. Aug 1987, 6 (3): 205–12. PMID 2885163. doi:10.1089/dna.1987.6.205. 
  2. ↑ Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN. A reevaluation of the amino acid sequence of human follitropin beta-subunit. J Protein Chem. Sep 1989, 7 (4): 325–39. PMID 3151250. doi:10.1007/BF01024882. 
  3. ↑ 3.0 3.1 Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide. 

延伸阅读

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  • Saxena BB, Rathnam P. Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands. J. Biol. Chem. 1976, 251 (4): 993–1005. PMID 1249074. 
  • Keene JL; Matzuk MM; Otani T; et al. Expression of biologically active human follitropin in Chinese hamster ovary cells. J. Biol. Chem. 1989, 264 (9): 4769–75. PMID 2494176.  已忽略未知参数|author-separator= (帮助)
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  • Shome B, Parlow AF. Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb). J. Clin. Endocrinol. Metab. 1974, 39 (1): 203–5. PMID 4835136. doi:10.1210/jcem-39-1-203. 
  • Fujiki Y, Rathnam P, Saxena BB. Studies on the disulfide bonds in human pituitary follicle-stimulating hormone. Biochim. Biophys. Acta. 1980, 624 (2): 428–35. PMID 6774759. 
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  • Matthews CH; Borgato S; Beck-Peccoz P; et al. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Nat. Genet. 1993, 5 (1): 83–6. PMID 8220432. doi:10.1038/ng0993-83.  已忽略未知参数|author-separator= (帮助)
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  • Grasso P, Rozhavskaya-Arena M, Reichert LE. Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle. Regul. Pept. 1999, 81 (1–3): 67–71. PMID 10395410. doi:10.1016/S0167-0115(99)00022-1. 
  • Ben-Menahem D; Hyde R; Pixley M; et al. Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation. Biochemistry. 1999, 38 (46): 15070–7. PMID 10563789. doi:10.1021/bi991510c.  已忽略未知参数|author-separator= (帮助)
  • Dias Neto E; Correa RG; Verjovski-Almeida S; et al. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (7): 3491–6. PMC 16267 可免费查阅. PMID 10737800. doi:10.1073/pnas.97.7.3491.  已忽略未知参数|author-separator= (帮助)
  • Hartley JL, Temple GF, Brasch MA. DNA Cloning Using In Vitro Site-Specific Recombination. Genome Res. 2001, 10 (11): 1788–95. PMC 310948 可免费查阅. PMID 11076863. doi:10.1101/gr.143000. 
  • Fox KM, Dias JA, Van Roey P. Three-dimensional structure of human follicle-stimulating hormone. Mol. Endocrinol. 2001, 15 (3): 378–89. PMID 11222739. doi:10.1210/me.15.3.378. 
  • Amoresano A; Orrù S; Siciliano RA; et al. Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain. Biol. Chem. 2002, 382 (6): 961–8. PMID 11501762. doi:10.1515/BC.2001.120.  已忽略未知参数|author-separator= (帮助)
  • Walton WJ; Nguyen VT; Butnev VY; et al. Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit. J. Clin. Endocrinol. Metab. 2001, 86 (8): 3675–85. PMID 11502795. doi:10.1210/jc.86.8.3675.  已忽略未知参数|author-separator= (帮助)
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