血管活性肠肽（Vasoactive intestinal peptide），常简称VIP，属于一种可促进肠道血管活性的肽类激素，由28个氨基酸残基组成。本蛋白属于升糖素/胰泌素超家族，为第二型G蛋白偶联受体的配体[1]。VIP在许多脊椎动物身上皆存在，包含肠、胰脏，以及下丘脑视上核[2][3][4]。VIP能刺激心脏收缩力、血管舒张、增加糖原分解、降低动脉血压，以及促进气管、胃、胆囊平滑肌舒张。在人类体内，该蛋白的编码基因为“VIP”[5]
参考文献
参考文献
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- ↑ Juhász T, Helgadottir SL, Tamás A, Reglődi D, Zákány R. PACAP and VIP signaling in chondrogenesis and osteogenesis. Peptides. 2015-04, 66: 51–7. PMID 25701761. doi:10.1016/j.peptides.2015.02.001.
- ↑ Delgado M, Ganea D. Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions. Amino Acids. 2013-07, 45 (1): 25–39. PMC 3883350
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- ↑ Fahrenkrug J. VIP and PACAP. Results and Problems in Cell Differentiation. 2010-01-01, 50: 221–34. PMID 19859678. doi:10.1007/400_2009_24.
- ↑ Hahm SH, Eiden LE. Cis-regulatory elements controlling basal and inducible VIP gene transcription. Annals of the New York Academy of Sciences. 1998-12, 865: 10–26. PMID 9927992.
- ↑ Henning RJ, Sawmiller DR. Vasoactive intestinal peptide: cardiovascular effects. Cardiovascular Research. 2001-01, 49 (1): 27–37. PMID 11121793.
延伸阅读
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