胆囊收缩素

Cholecystokinin; 胆囊收缩素
标识
代号	CCK; MGC117187
扩展标识	遗传学：118440 同源基因：583 ChEMBL: 1649050 GeneCards: CCK Gene
基因本体论描述
分子功能	· hormone activity; · neuropeptide hormone activity;
细胞成分	· extracellular region; · extracellular space; · axon; · dendrite; · axon initial segment; · terminal bouton; · axon hillock; · perikaryon;
生物过程	· behavioral fear response; · neuron migration; · release of cytochrome c from mitochondria; · activation of cysteine-type endopeptidase activity involved in apoptotic process; · signal transduction; · protein kinase C-activating G-protein coupled receptor signaling pathway; · axonogenesis; · positive regulation of cell proliferation; · negative regulation of appetite; · positive regulation of protein oligomerization; · eating behavior; · positive regulation of apoptotic process; · positive regulation of peptidyl-tyrosine phosphorylation; · positive regulation of mitochondrial depolarization; · regulation of sensory perception of pain;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
	查; 论; 编;

胆囊收缩素（英语：cholecystokinin，简称CCK或CCK-PZ；词源来自于希腊语的chole，胆汁之意；cysto，囊状之意；kinin，移动之意；组合起来的意义为“移动胆汁之囊”）是一种消化系统当中的肽类激素，可以促进脂肪与蛋白质的消化。胆囊收缩素在此之前名为促胰酶素（pancreozymin），是由小肠的黏膜上皮细胞当中的I细胞所合成，并由十二指肠分泌；这会导致从胰脏与胆囊，各自释放消化酶与胆汁。胆囊收缩素也是一种食欲抑制剂。最近的证据暗示，胆囊收缩素在促进鸦片类药物的药物容许量，如吗啡和海洛因，扮演着重要角色，并且在经历鸦片类药物停药后的疼痛过敏经历有着部分的关联性^[1]^[2]。

参见

参考文献

↑ Kissin I, Bright CA, Bradley EL. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth. Analg. 2000, 91 (1): 110–6. PMID 10866896. doi:10.1097/00000539-200007000-00021.
↑ Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S. Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats. J. Pharmacol. Sci. 2007, 104 (2): 159–66. PMID 17558184. doi:10.1254/jphs.FP0070475.

外部链接

医学主题词表（MeSH）：Cholecystokinin

[pmid10866896-1] Kissin I, Bright CA, Bradley EL. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth. Analg. 2000, 91 (1): 110–6. PMID 10866896. doi:10.1097/00000539-200007000-00021.

[pmid17558184-2] Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S. Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats. J. Pharmacol. Sci. 2007, 104 (2): 159–66. PMID 17558184. doi:10.1254/jphs.FP0070475.

[1]

[2]