腺苷A2B受体

腺苷A_2B受体(Adenosine A_2B receptor)，也称为ADORA2B，是腺苷受体其中的一种G蛋白偶联受体，也表示编码它的人类腺苷A_2b受体基因。

延伸阅读

• Stiles GL. Adenosine receptors.. J. Biol. Chem. 1992, 267 (10): 6451–4. PMID 1551861. 
• Pierce KD, Furlong TJ, Selbie LA, Shine J. Molecular cloning and expression of an adenosine A2b receptor from human brain.. Biochem. Biophys. Res. Commun. 1992, 187 (1): 86–93. PMID 1325798. doi:10.1016/S0006-291X(05)81462-7. 
• Li Q, Han X, Lan X, Hong X, Li Q, Gao Y, Luo T, Yang Q, Koehler RC, Zhai Y, Zhou J, Wang J. Inhibition of tPA-induced hemorrhagic transformation involves adenosine A2b receptor activation after cerebral ischemia.. Neurobiology of Disease. 2017, 108: 173–182. PMC 5675803 . PMID 28830843. doi:10.1016/j.nbd.2017.08.011. 
• Jacobson MA, Johnson RG, Luneau CJ, Salvatore CA. Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene.. Genomics. 1995, 27 (2): 374–6. PMID 7558011. doi:10.1006/geno.1995.1061. 
• Townsend-Nicholson A, Baker E, Sutherland GR, Schofield PR. Localization of the adenosine A2b receptor subtype gene (ADORA2B) to chromosome 17p11.2-p12 by FISH and PCR screening of somatic cell hybrids.. Genomics. 1995, 25 (2): 605–7. PMID 7790006. doi:10.1016/0888-7543(95)80074-V. 
• Strohmeier GR, Reppert SM, Lencer WI, Madara JL. The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia.. J. Biol. Chem. 1995, 270 (5): 2387–94. PMID 7836474. doi:10.1074/jbc.270.5.2387 . 
• Feoktistov I, Murray JJ, Biaggioni I. Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells.. Mol. Pharmacol. 1994, 45 (6): 1160–7. PMID 8022409. 
• Mirabet M, Herrera C, Cordero OJ, et al. Expression of A2B adenosine receptors in human lymphocytes: their role in T cell activation.. J. Cell Sci. 1999, 112 (4): 491–502. PMID 9914161. 
• Feoktistov I, Goldstein AE, Biaggioni I. Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells.. Mol. Pharmacol. 1999, 55 (4): 726–34. PMID 10101031. 
• Corset V, Nguyen-Ba-Charvet KT, Forcet C, et al. Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor.. Nature. 2000, 407 (6805): 747–50. PMID 11048721. S2CID 4423128. doi:10.1038/35037600. 
• Herrera C, Casadó V, Ciruela F, et al. Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells.. Mol. Pharmacol. 2001, 59 (1): 127–34. PMID 11125033. doi:10.1124/mol.59.1.127. 
• Christofi FL, Zhang H, Yu JG, et al. Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system.. J. Comp. Neurol. 2001, 439 (1): 46–64. PMID 11579381. S2CID 46222306. doi:10.1002/cne.1334. 
• Hayallah AM, Sandoval-Ramírez J, Reith U, et al. 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.. J. Med. Chem. 2002, 45 (7): 1500–10. PMID 11906291. doi:10.1021/jm011049y. 
• Sitaraman SV, Wang L, Wong M, et al. The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation.. J. Biol. Chem. 2002, 277 (36): 33188–95. PMID 12080047. doi:10.1074/jbc.M202522200 . 
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proceedings of the National Academy of Sciences of the United States of America. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. 
• Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors.. Circ. Res. 2003, 92 (5): 485–92. PMID 12600879. doi:10.1161/01.RES.0000061572.10929.2D . 
• Eltzschig HK, Ibla JC, Furuta GT, et al. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors.. J. Exp. Med. 2003, 198 (5): 783–96. PMC 2194189 . PMID 12939345. doi:10.1084/jem.20030891. 
• Ryzhov S, Goldstein AE, Matafonov A, et al. Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma.. J. Immunol. 2004, 172 (12): 7726–33. PMID 15187156. doi:10.4049/jimmunol.172.12.7726 . 
• Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. 
• Kolachala V, Asamoah V, Wang L, et al. Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase.. J. Biol. Chem. 2005, 280 (6): 4048–57. PMID 15550390. doi:10.1074/jbc.M409577200 . 

外部链接

• Adenosine Receptors: A_2B. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• Human ADORA2B genome location and ADORA2B gene details page in the UCSC Genome Browser.

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