3-羥酰輔酶A脫氫酶
3-羥酰輔酶A脫氫酶的結構（PDB 3had）
命名
系統命名
(S )-3-hydroxyacyl-CoA:NAD+ oxidoreductase
縮寫
別名
β-hydroxyacyl dehydrogenase; β-keto-reductase; 3-keto reductase; 3-hydroxyacyl coenzyme A dehydrogenase; β-hydroxyacyl-coenzyme A synthetase; β-hydroxyacylcoenzyme A dehydrogenase; β-hydroxybutyrylcoenzyme A dehydrogenase; 3-hydroxyacetyl-coenzyme A dehydrogenase; L-3-hydroxyacyl coenzyme A dehydrogenase; L-3-hydroxyacyl CoA dehydrogenase; β-hydroxyacyl CoA dehydrogenase; 3β-hydroxyacyl coenzyme A dehydrogenase; 3-hydroxybutyryl-CoA dehydrogenase; β-ketoacyl-CoA reductase; β-hydroxy acid dehydrogenase; 3-L-hydroxyacyl-CoA dehydrogenase; 3-hydroxyisobutyryl-CoA dehydrogenase; 1-specific DPN-linked β-hydroxybutyric dehydrogenase
識別碼
EC編號
1.1.1.35
CAS號
9028-40-4
數據庫
IntEnz
IntEnz瀏覽
BRENDA
BRENDA入口
ExPASy
NiceZyme瀏覽
KEGG
KEGG入口
MetaCyc
代謝路徑
PRIAM
概述
PDB
RCSB PDB PDBj PDBe PDBsum
基因本體
AmiGO / EGO
3-羥酰輔酶A脫氫酶 （英語：3-hydroxyacyl-CoA dehydrogenase ，EC 1.1.1.35 ）是一種以NAD+ 或NADP+ 為受體 、作用於供體 CH -OH 基團 上的氧化還原酶 。這種酶 能催化 以下酶促反應 ：
(S )-3-羥酰輔酶A + NAD+
⇌
{\displaystyle \rightleftharpoons}
3-氧酰輔酶A + NADH + H+ 3-羥酰輔酶A脫氫酶主要參與脂肪酸 的代謝 過程，如β-氧化 的第三步等。
參考文獻
Hillmer P and Gottschalk G. Solubilization and partial characterisation of particulate dehydrogenases from Clostridium kluyveri. Biochim. Biophys. Acta. 1974, 334 : 12–23. Lehninger AL, Greville GD. The enzymic oxidation of alpha- and 2-beta-hydroxybutyrate. Biochim. Biophys. Acta. 1953, 12 (1-2): 188–202. PMID 13115428 doi:10.1016/0006-3002(53)90138-3 Stern JR. Crystalline beta-hydroxybutyryl dehydrogenase from pig heart. Biochim. Biophys. Acta. 1957-11, 26 (2): 448–9. PMID 13499396 doi:10.1016/0006-3002(57)90040-9 Wakil SJ, Green DE, Mii S and Mahler HR. Studies on the fatty acid oxidizing system of animal tissues. VI. beta-Hydroxyacyl coenzyme A dehydrogenase. J. Biol. Chem. 1954-04, 207 (2): 631–8. PMID 13163047
