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核因子活化B細胞κ輕鏈增強子（英語：nuclear factor kappa-light-chain-enhancer of activated B cells，簡稱為NF-κB）是一種控制DNA轉錄的蛋白複合體。NF-κB幾乎存在於所有類型的動物細胞中並參與細胞對諸多刺激的響應，這些刺激包括應激、細胞因子、自由基、紫外線照射、氧化LDL及細菌或病毒抗原[1][2][3][4][5]。在針對感染的免疫反應中，NF-κB起到了重要的調節作用（κ輕鏈是免疫球蛋白的重要組成部分）。NF-κB的調控失常與癌症、炎症和自體免疫病、感染性休克、病毒感染以及免疫發育異常有關。NF-κB亦與突觸可塑性及記憶過程有着密切關係[6][7][8][9][10]
參考文獻
- ↑ 1.0 1.1 Gilmore TD. Introduction to NF-κB: players, pathways, perspectives. Oncogene. 2006, 25 (51): 6680–4. PMID 17072321. doi:10.1038/sj.onc.1209954.
- ↑ 2.0 2.1 Brasier AR. The NF-κB regulatory network. Cardiovasc. Toxicol. 2006, 6 (2): 111–30. PMID 17303919. doi:10.1385/CT:6:2:111.
- ↑ 3.0 3.1 Perkins ND. Integrating cell-signalling pathways with NF-κB and IKK function. Nat. Rev. Mol. Cell Biol. 2007-01, 8 (1): 49–62. PMID 17183360. doi:10.1038/nrm2083.
- ↑ Gilmore TD. The Rel/NF-κB signal transduction pathway: introduction. Oncogene. 1999, 18 (49): 6842–4. PMID 10602459. doi:10.1038/sj.onc.1203237.
- ↑ Tian B, Brasier AR. Identification of a nuclear factor κ B-dependent gene network. Recent Prog. Horm. Res. 2003, 58: 95–130. PMID 12795416. doi:10.1210/rp.58.1.95.
- ↑ Albensi BC, Mattson MP. Evidence for the involvement of TNF and NF-κB in hippocampal synaptic plasticity. Synapse. 2000, 35 (2): 151–9. PMID 10611641. doi:10.1002/(SICI)1098-2396(200002)35:2<151::AID-SYN8>3.0.CO;2-P.
- ↑ Meffert MK, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D. NF-kappa B functions in synaptic signaling and behavior. Nat. Neurosci. 2003-10, 6 (10): 1072–8. PMID 12947408. doi:10.1038/nn1110.
- ↑ Levenson JM, Choi S, Lee SY, Cao YA, Ahn HJ, Worley KC, Pizzi M, Liou HC, Sweatt JD. A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel. J. Neurosci. 2004-04, 24 (16): 3933–43. PMID 15102909. doi:10.1523/JNEUROSCI.5646-03.2004.
- ↑ Freudenthal R, Locatelli F, Hermitte G, Maldonado H, Lafourcade C, Delorenzi A, Romano A. Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus. Neurosci. Lett. 1998-02, 242 (3): 143–6. PMID 9530926. doi:10.1016/S0304-3940(98)00059-7.
- ↑ Merlo E, Freudenthal R, Romano A. The IkappaB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus. Neuroscience. 2002, 112 (1): 161–72. PMID 12044481. doi:10.1016/S0306-4522(02)00049-0.
外部連結
- 醫學主題詞表（MeSH）：NF-kappa+B
- Sankar Ghosh. Handbook of Transcription Factor NF-κB. Boca Raton: CRC. 2006. ISBN 0-8493-2794-6.
- Thomas D Gilmore. The Rel/NF-κB Signal Transduction Pathway. Boston University. [2007-12-02].