视网膜母细胞瘤蛋白

求闻百科，共笔求闻

视网膜母细胞瘤蛋白（英语：retinoblastoma protein，常缩写为Rb、RB或RB1）又译为成视网膜细胞瘤蛋白是一种抑癌蛋白，并在几种主要的癌症发生时失活[1]。Rb的功能之一是通过抑制细胞周期进程直到细胞准备妥当来防止细胞过度生长。当细胞准备好要分裂时，Rb蛋白会被磷酸化为pRb而失去抑制活性，从而使细胞周期进行下去。

Rb是袋状蛋白家族的一员，其特点是有一个口袋状的结构用以结合其它蛋白[2][3]。使得一些致癌变蛋白，比如高危险群人类乳突病毒所感染的细胞产生的蛋白，结合并抑制pRb，最终导致癌症。

相互作用

已知Rb蛋白与下列蛋白质有相互作用关系：

细胞凋亡中涉及的信号通路一览

参考文献

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  78. ↑ Hannan KM, Hannan RD, Smith SD, Jefferson LS, Lun M, Rothblum LI. Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. Oncogene. 2000-10, 19 (43): 4988–99. PMID 11042686. doi:10.1038/sj.onc.1203875. 
  79. ↑ Blanchette P, Gilchrist CA, Baker RT, Gray DA. Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130. Oncogene. 2001-09, 20 (39): 5533–7. PMID 11571651. doi:10.1038/sj.onc.1204823. 

视网膜母细胞瘤蛋白引用了美国国家医学图书馆提供的资料，这些资料属于公有领域。


延伸阅读

外部链接

参见

转录辅调节因子
共激活因子
共阻遏因子
ATP-依赖性重塑因子
参见:transcription factor/coregulator deficiencies
遗传学索引
描述
疾病
新生物：肿瘤抑制基因/蛋白与癌基因/原癌基因
配体
生长因子
受体
Wnt信号通路
刺猬信号通路
TGFβ信号通路
受体酪氨酸激酶
JAK-STAT信号通路
胞内信号P+P
Wnt信号通路
TGFβ信号通路
Akt/PKB信号通路
河马信号通路
TSP：神经纤维瘤蛋白2/膜突样蛋白
MAPK/ERK途径
其他/未知
核
细胞周期
DNA修复/范科尼
泛素连接酶
转录因子
线粒体
其他/未分组
医学导航: 肿瘤基因/标志肿瘤/同名/附瘤药物 (L1i/1e/V03)
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