苯丙酸诺龙

**苯丙酸诺龙**
系统（IUPAC）命名名称
	[(8R,9S,10R,13S,14S,17S)-13-methyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl] 3-phenylpropanoate
临床数据
商品名	Durabolin, others
妊娠分级	AU: D ; US: X (禁忌) ; ;
给药途径	Intramuscular injection
合法状态
合法状态	AU: 限医生处方 (S4) ; CA: Schedule IV ; UK: Class C ; US: Schedule III ;
药代动力学数据
生物利用度	• Oral: 0.3–2.9% (pigs); • Intramuscular: high
代谢	Blood (hydrolysis), liver (reduction)
代谢产物	• Nandrolone; • 5α-Dihydronandrolone; • 19-Norandrosterone; • 19-Noretiocholanolone; • Conjugates
生物半衰期	• Intramuscular: 2.7 days; • Nandrolone: <4.3 hours
作用时间	• Intramuscular: 5–7 days
排泄	Urine
识别信息
CAS注册号	434-22-0
PubChem	CID 229455
ChemSpider	199761
UNII	KF7Z9K2T3W
其他名称	• NPP; • Nandrolone phenpropionate; • 19-Nortestosterone phenylpropionate; • Nandrolone hydrocinnamate; • 19-Nortestosterone 17β-phenylpropionate; • NSC-23162
化学信息
化学式	C27H34O3
摩尔质量	406.57 g·mol−1
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OC(=O)CCC4=CC=CC=C4)CCC5=CC(=O)CC[C@H]35; ;
	InChI InChI=1S/C27H34O3/c1-27-16-15-22-21-11-9-20(28)17-19(21)8-10-23(22)24(27)12-13-25(27)30-26(29)14-7-18-5-3-2-4-6-18/h2-6,17,21-25H,7-16H2,1H3/t21-,22+,23+,24-,25-,27-/m0/s1; Key:UBWXUGDQUBIEIZ-QNTYDACNSA-N;

苯丙酸诺龙（英语：Nandrolone phenylpropionate或 Nandrolone hydrocinnamic，缩写NPP，商品名为Durabolin）是一种雄激素同化类固醇（AAS）药物，主要用于治疗乳腺癌和骨质疏松症女性^[5]^[8]^[9]^[10]^[11]，通过每周一次的肌肉注射进行^[5]。这类药物过去曾广泛应用，但现已逐渐停用^[5]^[11]。

参考文献

↑ McEvoy JD, McVeigh CE, McCaughey WJ. Residues of nortestosterone esters at injection sites. Part 1. Oral bioavailability. Analyst. 1998, 123 (12): 2475–8. PMID 10435281. doi:10.1039/a804919j.
↑ Kenneth L. Becker. Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. 2001: 1185–. ISBN 978-0-7817-1750-2.
↑ ^3.0 ^3.1 ^3.2 http://www.medsafe.govt.nz/profs/Datasheet/d/Decadurabolininj.pdf
↑ ^4.0 ^4.1 John A. Thomas. Drugs, Athletes, and Physical Performance. Springer Science & Business Media. 2012-12-06: 27–29. ISBN 978-1-4684-5499-4.
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 William Llewellyn. Anabolics. Molecular Nutrition Llc. 2011: 460–467,193–194. ISBN 978-0-9828280-1-4.
↑ ^6.0 ^6.1 Victor A. Rogozkin. Metabolism of Anabolic-Androgenic Steroids. CRC Press. 1991-06-14: 108–. ISBN 978-0-8493-6415-0.
↑ ^7.0 ^7.1 Minto CF, Howe C, Wishart S, Conway AJ, Handelsman DJ. Pharmacokinetics and pharmacodynamics of nandrolone esters in oil vehicle: effects of ester, injection site and injection volume. J. Pharmacol. Exp. Ther. 1997, 281 (1): 93–102. PMID 9103484.
↑ J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 2014-11-14: 660–. ISBN 978-1-4757-2085-3.
↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000-01: 716–717. ISBN 978-3-88763-075-1.
↑ I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 2012-12-06. ISBN 978-94-011-4439-1.
↑ ^11.0 ^11.1 存档副本. [2019-02-17].

[pmid10435281-1] McEvoy JD, McVeigh CE, McCaughey WJ. Residues of nortestosterone esters at injection sites. Part 1. Oral bioavailability. Analyst. 1998, 123 (12): 2475–8. PMID 10435281. doi:10.1039/a804919j.

[Becker2001-2] Kenneth L. Becker. Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. 2001: 1185–. ISBN 978-0-7817-1750-2.

[Label-NZ-3] 3.0 ^3.1 ^3.2 http://www.medsafe.govt.nz/profs/Datasheet/d/Decadurabolininj.pdf

[Thomas2012-4] 4.0 ^4.1 John A. Thomas. Drugs, Athletes, and Physical Performance. Springer Science & Business Media. 2012-12-06: 27–29. ISBN 978-1-4684-5499-4.

[Llewellyn2011-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 William Llewellyn. Anabolics. Molecular Nutrition Llc. 2011: 460–467,193–194. ISBN 978-0-9828280-1-4.

[Rogozkin1991-6] 6.0 ^6.1 Victor A. Rogozkin. Metabolism of Anabolic-Androgenic Steroids. CRC Press. 1991-06-14: 108–. ISBN 978-0-8493-6415-0.

[pmid9103484-7] 7.0 ^7.1 Minto CF, Howe C, Wishart S, Conway AJ, Handelsman DJ. Pharmacokinetics and pharmacodynamics of nandrolone esters in oil vehicle: effects of ester, injection site and injection volume. J. Pharmacol. Exp. Ther. 1997, 281 (1): 93–102. PMID 9103484.

[Elks2014-8] J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 2014-11-14: 660–. ISBN 978-1-4757-2085-3.

[IndexNominum2000-9] Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000-01: 716–717. ISBN 978-3-88763-075-1.

[MortonHall2012-10] I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 2012-12-06. ISBN 978-94-011-4439-1.

[Drugs.com-11] 11.0 ^11.1 存档副本. [2019-02-17].

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