肌球蛋白轻链激酶

myosin light-chain kinase 3, cardiac
识别
符号	MYLK3
Entrez	91807
HUGO	29826
OMIM	612147
RefSeq	NM_182493
UniProt	Q32MK0
其他资料
基因座	16 q11.2

myosin light-chain kinase 2, skeletal muscle
	Crystal structure of the S. dubia centrin / human skeletal muscle myosin light-chain complex.
识别
符号	MYLK2
Entrez	85366
HUGO	16243
OMIM	606566
RefSeq	NM_033118
UniProt	Q9H1R3
其他资料
基因座	20 q13.31

肌球蛋白轻多肽激酶，平滑肌
识别
符号	MYLK
Entrez	4638
HUGO	7590
OMIM	600922
RefSeq	NM_053025
UniProt	Q15746
其他资料
EC编号	2.7.11.18
基因座	3 qcen-q21

人类肌球蛋白轻链激酶

The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156.^[2]
识别
符号	MYLK4
Entrez	340156
HUGO	27972
RefSeq	NM_001012418
UniProt	Q86YV6
其他资料

肌球蛋白轻链激酶（英语：Myosin light-chain kinase，MYLK 或 MLCK）是一类丝氨酸/苏氨酸特异性蛋白激酶，通过磷酸化来调节II型肌球蛋白的轻链^[3]。

亚型

现存四种MLCK亚型^[4]主要分布于不同肌细胞：

MYLK – 平滑肌
MYLK2 – 骨骼肌
MYLK3 – 心肌
MYLK4 – 未知

功能

另见

蛋白激酶A

参考文献

↑ RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex.
↑ RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156..
↑ Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K. Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction. IUBMB Life. June 2001, 51 (6): 337–44. PMID 11758800. doi:10.1080/152165401753366087.
↑ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. December 2002, 298 (5600): 1912–34. PMID 12471243. doi:10.1126/science.1075762.

延伸阅读

Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Clayburgh DR, Rosen S, Witkowski ED; et al. A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.. J. Biol. Chem. 2005, 279 (53): 55506–13. PMC 1237105 . PMID 15507455. doi:10.1074/jbc.M408822200.
Wang F, Graham WV, Wang Y; et al. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.. Am. J. Pathol. 2005, 166 (2): 409–19. PMC 1237049 . PMID 15681825. doi:10.1016/S0002-9440(10)62264-X.
Russo JM, Florian P, Shen L; et al. Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.. Gastroenterology. 2005, 128 (4): 987–1001. PMC 1237051 . PMID 15825080. doi:10.1053/j.gastro.2005.01.004.
Shimizu S, Yoshida T, Wakamori M; et al. Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.. J. Physiol. (Lond.). 2006, 570 (Pt 2): 219–35. PMC 1464317 . PMID 16284075. doi:10.1113/jphysiol.2005.097998.
Kim MT, Kim BJ, Lee JH; et al. Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells.. Am. J. Physiol., Cell Physiol. 2006, 290 (4): C1031–40. PMID 16306123. doi:10.1152/ajpcell.00602.2004.
Kimura K, Wakamatsu A, Suzuki Y; et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 2006, 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Connell LE, Helfman DM. Myosin light chain kinase plays a role in the regulation of epithelial cell survival.. J. Cell. Sci. 2007, 119 (Pt 11): 2269–81. PMID 16723733. doi:10.1242/jcs.02926.
Seguchi O, Takashima S, Yamazaki S; et al. A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.. J. Clin. Invest. 2007, 117 (10): 2812–24. PMC 1978424 . PMID 17885681. doi:10.1172/JCI30804.

外部链接

肌球蛋白轻链激酶引用了美国国家医学图书馆提供的资料，这些资料属于公有领域。

[3KF9-1] RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex.

[2X4F-2] RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156..

[pmid11758800-3] Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K. Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction. IUBMB Life. June 2001, 51 (6): 337–44. PMID 11758800. doi:10.1080/152165401753366087.

[pmid12471243-4] Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. December 2002, 298 (5600): 1912–34. PMID 12471243. doi:10.1126/science.1075762.

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[2]

[3]

[4]

myosin light-chain kinase 2, skeletal muscle

Crystal structure of the S. dubia centrin / human skeletal muscle myosin light-chain complex.^[1]
识别
符号	MYLK2
Entrez	85366
HUGO	16243
OMIM	606566
RefSeq	NM_033118
UniProt	Q9H1R3
其他资料
基因座	20 q13.31