胰岛素样生长因子1:修订间差异

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'''胰岛素样生长因子1'''({{lang-en|Insulin-like growth factor 1}},'''IGF-1''')也被称为'''生长调节素C'''(somatomedin C),是一个由人类[[基因]] ''IGF1'' 编码的[[蛋白质]]<ref name="pmid2982726">{{cite journal | vauthors = Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS | title = The human gene encoding insulin-like growth factor I is located on chromosome 12 | | journal = Hum. Genet. | volume = 69 | issue = 2 | pages = 157–60 | year = 1985 | pmid = 2982726 | doi = 10.1007/BF00293288 }}</ref><ref name="pmid6358902">{{cite journal | vauthors = Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL | title = Sequence of cDNA encoding human insulin-like growth factor I precursor | journal = Nature | volume = 306 | issue = 5943 | pages = 609–11 | year = 1983 | pmid = 6358902 | doi = 10.1038/306609a0 }}</ref>。在1970年代,IGF-1也曾经被称为“{{le|酸硫化|sulfation}}因子”<ref>{{cite journal | vauthors = Salmon WD, Daughaday WH | title = A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro | journal = J Lab Clin Med | volume = 49 | issue = 6 | pages = 825–36 | year = 1957 | pmid = 13429201 }}</ref>,並認為其作用为“不受抑制的胰岛样活力”(nonsuppressible insulin-like activity,NSILA)。
'''胰岛素样生长因子1'''({{lang-en|Insulin-like growth factor 1}},'''IGF-1''')也被称为'''生长调节素C'''(somatomedin C),是一个由人类[[基因]] ''IGF1'' 编码的[[蛋白质]]<ref name="pmid2982726">{{cite journal | vauthors = Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS | title = The human gene encoding insulin-like growth factor I is located on chromosome 12 | | journal = Hum. Genet. | volume = 69 | issue = 2 | pages = 157–60 | year = 1985 | pmid = 2982726 | doi = 10.1007/BF00293288 }}</ref><ref name="pmid6358902">{{cite journal | vauthors = Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL | title = Sequence of cDNA encoding human insulin-like growth factor I precursor | journal = Nature | volume = 306 | issue = 5943 | pages = 609–11 | year = 1983 | pmid = 6358902 | doi = 10.1038/306609a0 }}</ref>。在1970年代,IGF-1也曾经被称为“{{le|酸硫化|sulfation}}因子”<ref>{{cite journal | vauthors = Salmon WD, Daughaday WH | title = A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro | journal = J Lab Clin Med | volume = 49 | issue = 6 | pages = 825–36 | year = 1957 | pmid = 13429201 }}</ref>,並认为其作用为“不受抑制的胰岛样活力”(nonsuppressible insulin-like activity,NSILA)。


IGF-1是一个在[[三级结构]]上与[[胰岛素]]类似的[[激素]],在儿童成长发育中有重要作用,并持续在成人的[[同化作用|合成代谢]]中起作用。一种人工合成的IGF-1类似物,{{le|美卡舍明|mecasermin}},用于治疗发育停滞<ref name="pmid18481900">{{cite journal | vauthors = Keating GM | title = Mecasermin | journal = BioDrugs | volume = 22 | issue = 3 | pages = 177–88 | year = 2008 | pmid = 18481900 | doi = 10.2165/00063030-200822030-00004 }}</ref>。
IGF-1是一个在[[三级结构]]上与[[胰岛素]]类似的[[激素]],在儿童成长发育中有重要作用,并持续在成人的[[同化作用|合成代谢]]中起作用。一种人工合成的IGF-1类似物,{{le|美卡舍明|mecasermin}},用于治疗发育停滞<ref name="pmid18481900">{{cite journal | vauthors = Keating GM | title = Mecasermin | journal = BioDrugs | volume = 22 | issue = 3 | pages = 177–88 | year = 2008 | pmid = 18481900 | doi = 10.2165/00063030-200822030-00004 }}</ref>。